Cancer Science & Mechanisms to Therapies









Several scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancers in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated increased estrogen, and genetic polymorphisms. Here, we summarize the impact of the generation of reactive oxygen species, aberrant metabolism of folate and retinoids, alcohol drinking on the risk of cancers development and potential underlying molecular mechanisms. The interactions between alcohol abuse, anti-tumour immune response, tumor growth, and metastasis are complex. However, multiple studies have linked the immunosuppressive effects of alcohol with tumour progression and metastasis. The influence of alcohol on the host immune system and the development of possible effective immunotherapy for cancers in alcoholics are also discussed here. The conclusive biological effects of alcohol on tumor progression and malignancy have not been investigated extensively using an animal model that mimics the human disease. This review provides insights into cancers pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.


  • Impact of oncogenic signaling on metabolism
  • Metabolic wiring
  • Metabolic control of the epigenome
  • Targeting stroma metabolism
  • Metabolic heterogeneity and tumour progression
  • Targeting metabolic liabilities

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If due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within the period of one year from the date of rescheduling.

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If due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within the period of one year from the date of rescheduling.

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Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of the conferences.

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This cancellation policy was last updated on April 04, 2015.

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