Cancer Science & Cell Death Mechanisms to Novel Cancer Treatments
Despite remarkable progress in the discovery and
development of novel cancer therapeutics, cancer
remains the second leading cause of death in the world. For many years,
compounds derived from plants have been at the forefront as an important source
of anticancer therapies and have played a
vital role in the prevention and treatment of cancer because of their
availability, and relatively low toxicity when compared with chemotherapy. More
than 3000 plant species have been reported to treat cancer and
about thirty plant-derived compounds have been isolated so far and have been
tested in cancer clinical trials. The
mechanisms of action of plant-derived anticancer drugs are numerous and most of
them induce apoptotic cell death that may be intrinsic or extrinsic, and
caspase and/or p53-dependent or independent mechanisms. Alternative modes of
cell death by plant-derived anticancer drugs are emerging and include mainly
autophagy, necrosis-like programmed cell death, mitotic catastrophe, and
senescence leading to cell death. Considering that the non-apoptotic cell death
mechanisms of plant-derived anticancer drugs are less reviewed than the
apoptotic ones, this paper attempts to focus on such alternative cell death
pathways for some representative anticancer plant natural compounds in clinical
development. In particular, emphasis will be on some promising polyphenolics
such as resveratrol, curcumin, and genistein; alkaloids namely berberine,
noscapine, and colchicine; terpenoids such as parthenolide, triptolide, and
betulinic acid; and the organosulfur compound sulforaphane. The understanding
of non-apoptotic cell death mechanisms induced by these drugs would provide
insights into the possibility of exploiting novel molecular pathways and
targets of plant-derived compounds for future cancer therapeutics.
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If due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within the period of one year from the date of rescheduling.
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This cancellation policy was last updated on April 04, 2015.
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